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First, the effect is reproduced across multiple large Phase 3 trials in different populations, not a single program

Another crucial consideration is not combining tirzepatide with other GLP-1 medications unless explicitly directed by a healthcare provider

Administration and packaging: While both drugs require once weekly injections, Trulicity is only available in single-use pens (each pen is used one and then discarded) that should be stored in the refrigerator

Patent estate includes the Roche structure patent agreement ($100M upfront, Jan 2026)

long-term discontinuation data are still emerging from Phase 3 TRIUMPH trials