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Histamine intolerance implies impaired breakdown High histamine states may involve overproduction, mast cell activation, or inflammation Clues suggesting high histamine rather than simple intolerance: Symptoms unrelated to meals Nighttime anxiety or insomnia Sensory overstimulation Worsening with stress or hormonal shifts Clinical pattern recognition often matters more than isolated lab values
et al., J
10.1007/s00394-016-1376-9
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