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Apoptosis is a widely studied mild non-lytic mode of cell death characterized by a decrease in cell volume and fragmentation of the nucleus and involved in many diseases including diabetes [65]

Allopurinol is a prodrug that is metabolized to the purine analog, oxypurinol that is a structural isomer of hypoxanthine and leads to inhibition of xanthine oxidase activity

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DSIPs precise physiological role and mechanism of action continue to be subjects of ongoing research

It disrupts the balance of the tumor immune microenvironment by synergistically regulating immune cells, precisely antioxidant, and relieving immune suppression, forming a microenvironment conducive to anti-tumor immunity, thereby exerting a powerful cancer immunotherapy effect and showing good biocompatibility and tumor accumulation characteristics [427, 428]