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The STEP-1 trial demonstrated 14.9% mean body weight reduction at 68 weeks on 2.4mg weekly semaglutide

As dosing progresses under physician guidance, semaglutides metabolic effects become more pronounced

Disclosure form provided by the author is available with the article at ugeskriftet.dk/dmj Cite this as Dan Med J 2023;70(1):A10220597 Ls ogs Referencer Gasbjerg LS, Helsted MM, Hartmann B et al

High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels

This is especially relevant during the early weeks of treatment when eating habits are changing, and appetite suppression tends to be most pronounced