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The minimal differences in genetic effect estimates (Beta difference range: 0.001-0.003) between female and sex-combined data for the exposure-mediator relationships indicate that sex is not a major effect modifier at this step, validating the use of sex-combined data for these mediators in our primary analysis

The research supporting dual GIP and GLP-1 receptor agonism shows no time-of-day variation in receptor binding affinity or downstream metabolic effects

Copper is an essential trace element that plays a crucial role in various biological processes, including collagen production and wound healing

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Furthermore, it supports collagen synthesis, gut integrity, and tissue regeneration