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Switching to retatrutide Moving from a dual agonist (tirzepatide) to a triple agonist (retatrutide) is generally smoother because retatrutide maintains GLP-1 and GIP activation while adding glucagon receptor stimulation

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For instance, patients may experience symptoms such as numbness, tingling, and burning sensations, which can significantly impact their quality of life (Won et al., 2017

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