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31 Oxytocin is known to inhibit food intake and PWS is characterized by oxytocinergic dysfunction
Notably, the proposed binding mode is compatible with the simultaneous binding of the substrate L-Leu- p NA, in agreement with the uncompetitive IRAP inhibition determined for a representative compound
This can lead to prolonged development timelines and increased costs for pharmaceutical companies
Trials were conducted to study the potential effect of Semazic on the absorption of oral medicinal products taken with Semazic administered orally at steady state exposure
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