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the peptide Ac-Nle-cyc/o(- Asp-His-D-Phe-Arg-Trp-Lys)-OH is used in the manufacture of a medicament for intranasal administration for use in the treatment of erectile dysfunction in a male, wherein the peptide Ac-Nle- cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH increases cGMP levels to an amount sufficient to produce an erection sufficient for sexual intercourse when the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp- Lys)-OH is administered at a sub-therapeutic dose and administered subsequent to a sub- therapeutic dose of a PDE-5 inhibitor

PMID: 40628573 ) Schol J, Huang IH, Carbone F, Fernandez LMB, Gourcerol G, Ho V, Kohn G, Lacy BE, Colombo AL, Miwa H, Moshiree B, Nguyen L, OGrady G, Siah KTH, Stanghellini V, Tack J (2025) Rome Foundation and international neurogastroenterology and motility societies consensus on idiopathic gastroparesis

Profile of adipose tissue gene expression in premenopausal and postmenopausal women: site-specific differences