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Strong evidence from randomised controlled trials clearly shows that these agents reduce the risk of chronic kidney disease (CKD) progression, mortality and cardiovascular events in adults with type 2 diabetes and CKD

Increasing protein intake to 30-35% of daily calories preserves muscle mass (which naturally declines during weight loss), maintains metabolic rate, and triggers satiety signals independent of medication

While this research is promising, more studies and clearer guidance on less-frequent dosing are still needed

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