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For instance, tumours with high endogenous CCNE1 expression, which encodes the oncogene cyclin E1, are HR proficient and inherently resistant to DNA-damaging agents 6

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Cell Mol Life Sci 72:13311345 Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, Vatner DE, Vatner SF (2002) The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

Domperidone and certain anti-nausea medications may also interact negatively with semaglutide's mechanism of action