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Significant impairment of biliary copper transport can permit copper accumulation in the liver

Bioorg Chem 77:223235 Yazdani M, Edraki N, Badri R, Khoshneviszadeh M, Iraji A, Firuzi O (2019) Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: design, synthesis and biological evaluation

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(1) This level remains unaffected regardless of whether youre well-hydrated while drinking