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Multi-factorial risk scoring incorporates patient factors, medication characteristics, and procedural requirements to stratify patients into low, moderate, and high-risk categories [54]

Treasure Island (FL: StatPearls Publishing (2025)

Physiol Rev 59:527605 Ng CF, Schafer FQ, Buettner GR, Rodgers VG (2007) The rate of cellular hydrogen peroxide removal shows dependency on GSH: mathematical insight into in vivo H2O2 and GPx concentrations

This hormone, in turn, inhibits osteoclastic activity, which decreases the release of calcium from the bone into the bloodstream, leading to decreased bone resorption [56, 57]

Most patients experience peak nausea and GI effects during weeks 1-4 after dose increases, with significant improvement by weeks 4-8 as your body adapts