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Obesity rates in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study cohort rose from 1% in 19831985 to 31% by 2005 (ref

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Immunosuppressants (azathioprine, mercaptopurine) and biologic therapies (anti-TNF agents, vedolizumab, ustekinumab) are reserved for steroid-dependent or steroid-refractory disease

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