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The practical difference for most people is minimal, though methylcobalamin skips the conversion step and may be preferable for individuals with certain genetic variations affecting B12 metabolism

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Gregory Lubiniecki, vice president of oncology clinical research at Merck Research Laboratories, noted in a statement that prognoses are generally poor for this disease and said the company is pleased to offer a new first-line treatment option. The approval was backed by results from the Phase II/III KEYNOTE-483 trial, where Keytruda elicited a significant survival benefit for patients, cutting the risk of death by 21%

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