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Moreover, GH signaling to elicit IGF1 gene transcription is blocked in the absence of appropriate insulin signaling, a phenomenon also known as un-coupling, and resulting in growth arrest (60, 61, 63, 64) (Figure 3)

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doi: 10.1126/science.aav0173 62 UbellackerJMTasdoganARameshVShenBMitchellECMartin-SandovalMSet al

Lung Cancer 2011;71:182-5

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