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Another new insight came from knock-out of the mysterious type 2 IGF receptor, identical to the mannose-6 phosphate receptor (M6P-R), specifically binding IGF-II and involved in internalization of proteins for lysosomal degradation

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Most encouraging, both chronic and early course studies (Hogarty, Greenwald, and Eack, Psychiatric Services , 2006;57:1751-1757

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(III)Potential Clinical Significance: Current interventions for gastrointestinal dysfunction primarily rely on dietary adjustments and probiotic supplementation, with a lack of targeted pharmacological options