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The FDA officially announced semaglutide on shortage in March 2022, followed by tirzepatide and dulaglutide in December 2022, and liraglutide in July 2023.(8) Even today, two years later, the supply of these medications remains sparse

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Moreover, PI3K/Akt has been reported to be upregulated in migraine [64], but no study has provided a direct evidence of whether this pathway participates in the mechanism of CM

These results trail injectable semaglutide's 15-22% reductions but remain clinically significant for metabolic health

DOI: Received: Accepted: Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-97-9936-7 Online ISBN: 978-981-97-9936-7 eBook Packages: Living Reference Chemistry and Mat