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Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)

Conclusion GLP-1 medications can be a helpful tool for weight loss, but theyre not a one-size-fits-all solution

Cannot increase to a higher dose Sometimes, people do not feel as much appetite reduction with semaglutide because they are not able to increase to a higher dose, or they may not tolerate higher doses due to side effects like nausea or stomach upset, says Karalis, RD

Zepbound is FDA-approved specifically for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with weight-related conditions

But tirzepatide has specific clinical trial data showing impressive results