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Why did the investigators wash out the drug for 2 months after the primary outcome

Inadequate hydration concentrates urine, potentially irritating the bladder lining and creating a more favourable environment for bacterial growth

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Combined oral sodium butyrate and mesalazine treatment compared to oral mesalazine alone in ulcerative colitis - randomized, double-blind, placebo-controlled pilot study

People with autonomic nervous system problems (sometimes caused by diabetes or neurological conditions) may also have trouble adjusting to changes in blood pressure