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When you produce tears or have another liquid in your eyes, some of it drains into these holes and then into the lacrimal sac, the nasolacrimal duct, and eventually into the back of your nose and throat, where you might get a taste

[1] [14] However, this doesn't mean all doses are completely without risk of adverse effects or interactions (for example, chloramphenicol may reduce the haematological response to B12)

Injections of B12 may be given to patients who are unable to absorb this vitamin in their bodies due to problems such as gastrointestinal pathology or dysfunction

it has been proposed that starvation increases ketone body formation and that these would compete with paracetamol for CYP2E1 and may potentially reduce toxicity [82]