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Further reading [edit] Diagnostic Pathology: Head and Neck, 2nd edition

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3 Results 3.1 Development and verification of PBPK model in adults Observed plasma drug concentration data of adults receiving 5 mg single dose of tirzepatide in a clinical trial (Coskun et al., 2018) was chosen as training dataset for parameter optimization and the development of the adult model (Figure 2A), data from 5 clinical studies covering a broad range of 0.2515 mg in single (Figures 2BH) and multiple (Figures 3AE) dosing regimens were used as testing dataset for model external verification

Fifteen broadly neutralizing mAbs were isolated from macaques that could neutralize a panel of pseudoviruses carrying spike proteins of SARS-CoV-2 variants, including Omicron BA.1 and BA.4/5, and SARS-CoV-1 [147]