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Appendix Abbreviations AE(s): Adverse Event(s) BMI Body Mass Index CENTRAL Cochrane Central Register of Controlled Trials CI Confidence Interval CSF Cerebrospinal Fluid GLP-1 Glucagon-Like Peptide-1 GLP-1 RA(s) GLP-1 Receptor Agonist(s) I (Statistical measure of heterogeneity) ICP Intracranial Pressure IIH Idiopathic Intracranial Hypertension IQR Interquartile Ranges logMAR Logarithm of the Minimum Angle of Resolution MD Mean Difference NOS Newcastle-Ottawa Quality Assessment Scale PICO Population, Intervention, Comparison, and Outcomes PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses PROSPERO (International prospective register of systematic reviews Name, not an acronym defined in text) RCT(s) Randomized Controlled Trial(s) RoB2 Revised Cochrane risk-of-bias tool (for randomized trials) RR Risk Ratio SD Standard Deviation SMD Standardized Mean Difference ULN Upper Limit of Normal VRS Verbal Rating Scale WOS/WoS Web of Science Footnotes ORCID iDs: Jamal Ahmad Ahmed Mohamed Hamdy Bahaa Elfakharany Muhammad M

Exenatide represents an artificial 39-amino-acid version of exendin-4 derived from Gila monster venom, which contains roughly 50% sequence similarity to human GLP-1

It does not prescribe medications itself

The end result is a single molecule that can be injected once weekly and produces robust activation of both incretin pathways