Impaired wound healing is an indication of low levels of vitamin C, and supplementation with both oral and topical vitamin C is useful especially in individuals who may have a low vitamin C level baseline (such as smokers and heavy drinkers)
This new class of medication proved to be so effective, it was fast-tracked for FDA-approval as a weight loss medication
The question of whether weight loss on top of great medical therapy can lower events has been answered, and the effect is impressive
That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119
They can promote better metabolic health by boosting glucose control and insulin sensitivity, as in the case of GLP-1 receptor agonists for type 2 diabetes
![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
