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Directly stimulates the formation of new synaptic connections between neurons, increasing dendritic complexity, enhancing neural network density, and fundamentally expanding the brains information processing capacity

11 The well-known mechanism for p70S6K1 to promote survival is that p70S6K1 phosphorylates mouse double minute 2 (MDM2) leading to polyubiquitination and degradation of p53, and thus represses p53-dependent apoptosis

Decreased efficacy was observed when this dose was spread over two administrations (50 mg/kg i.p

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