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Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

Dresser, D

Structural analyses have revealed conserved architecture across family members, comprising three -helical elements encircling a central four-stranded -sheet core, with higher eukaryotes demonstrating supplementary secondary structure elements (19)

Last process review: June 10, 2026

Always provide your doctor with a full list of all medications and supplements you are taking