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Methods Eighty-two first-ever ischemic stroke patients were randomly assigned to either the L-carnitine group (1000 mg three times/day for seven consecutive days) or the matching placebo group

These results showed the importance of incorporating multiple metabolic networks in a single zonation model

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Another study found that increased mRNA expression in hepatic biological clock genes, a decrease in levels of key metabolism-regulating enzymes, hepatic inflammation and steatosis can occur, which is associated with glucose and fatty acid metabolism (111)