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The tail that wags the dog: how the disordered C-terminal domain controls the transcriptional activities of the p53 tumor-suppressor protein
Although genetics does play a large role in the timing of when you go gray, there are many modifiable lifestyle factors that influence graying hair, which is also known as canities or achromotrichia
Decreased glutathione levels, ROS accumulation, and increased inflammatory cytokines trigger follicular cell damage, apoptosis, and an autoimmune response (Lopes et al., 2022)
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Finkel, T
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