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By using mice deficient in glutamate-cysteine ligase (GCL) in keratinocytes, the authors found that GSH deficiency results in more DNA damage and cell death, suggesting a crucial role for the antioxidant capacity in skin integrity maintenance [93]

National Library of Medicine (2019)

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In hepatocellular carcinoma, glutathione S-transferase Pi (GSTP) translocates to the nucleus and modulates redox signaling via the Nrf2-Keap1 complex