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Many patients lose meaningful weight

A prespecified analysis of the FLOW trial evaluated the composite time to the first occurrence of heart failure events (including new onset or worsening heart failure that resulted in an unscheduled hospital admission or urgent visit) or CV death

Prioritizing protein helps preserve (or grow) lean muscle mass (especially important on a calorie reduction), maintain strength, and support healthy aging during weight loss

The added targets generally correlate with larger weight reductions in trials

Current guidance says most patients can continue, but your team will create a specific plan to ensure your safety during the procedure