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Ceramide 1

The T-tubules are specialized structures that allow the sarcolemma to be in contact with the membranes of the sarcoplasmic reticulum (SR)

Instead of simply raising or lowering one neurotransmitter, they tend to fine-tune the way different brain regions communicate

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Exclusion criteria for both the FEP and healthy control groups involved meeting criteria for a substance use disorder in the past year according to DSM-5 [36] criteria (this was based on self-report for controls, and in addition clinical assessment and urine drug screening done at the point of clinical assessment in suspected cases for patients), having a history of a major head injury (leading to a significant period of unconsciousness or seizures), having a significant, uncontrolled medical illness, or having any contraindications to undergoing MRI