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Because studies have evaluated GHK-Cu across multiple cell types (including fibroblasts and keratinocytes) and in preclinical models, it is commonly used to support mechanistic work on aging-related tissue changes, repair biology, and copper homeostasisstrictly within controlled research designs
However, after the MT binding capacity is saturated, a large amount of Cd ion is liberated into the cytosol and Cd can directly affect and damage the integrity of plasma membranes and intracellular organelles causing cell death 23,24
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