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In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells
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The most critical period for damage appears to be during the first trimester, resulting in birth defects affecting the cardiovascular system, central nervous system, facial area, and thymus (an organ involved in immune cell production)
