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The trans-3-hexenoic acid group sterically shields the N-terminal region from dipeptidyl peptidase IV (DPP-IV) cleavage, which is the primary route of GHRH degradation in vivo, resulting in meaningfully improved metabolic stability compared to native GHRH and sermorelin

Animal studies The animal study was approved by the Institutional Animal Care and Use Committee (IACUC) at Yonsei University (Seoul, Korea) under IACUC Approval No

In short, the complexity of these pathways may lead to inconsistent therapeutic effects and unexpected interactions

published online: 19 January 2017