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Transcobalamin II deficiency: A rare hereditary condition that affects how well vitamin B12 (cobalamin) is transported into the body Vitiligo Certain medications Symptoms Fatigue, sluggishness, depression, dyspnea, and nerve issues are some of the B12 deficiency symptoms
Key steps include leucine binding to the Sestrin2 protein, relieving its inhibition of the GATOR2 complex, subsequently promoting Rag GTPase complex activation, and ultimately recruiting mTORC1 to the lysosomal surface for activation by the Rheb protein ( Parallel pathological mechanisms beyond mTORC1
In rare cases, thiamine hypersensitivity, including urticaria, anaphylactoid reactions, collapse, and death have occurred, primarily following repeated parenteral administration
Trulicity is given once a week
Protein intake should reach 1.0-1.2 grams per pound of body weight daily
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