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The activated Trem2 signal in stage 1 DAM facilitates transition to stage 2 DAM, which is characterized by an upregulation of lysosomal, phagocytic, and lipid metabolism pathway-related genes including cst7 and itgax

Funding This work was supported by the University of Sydney Postdoctoral Research Fellowship to TD and by the University of Sydney to TD and JM

Unfortunately, methadone has failed to change with the times

Duration: 14 days

The above-presented body of literature in this review strongly supports the fact that there are several pharmacologic agents available to prevent, at least in part, this disability