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When Young happened upon Engs poster in San Francisco, he already knew about the shortcomings of synthetic GLP-1namely, that it lasted mere minutes in the bloodstream

Receptors GLP-1 GLP-1 + GIP GLP-1 + GIP + Glucagon Class Single-agonist Dual-agonist Triple-agonist Generation First Second Third Brand Names Ozempic / Wegovy Mounjaro / Zepbound Not yet approved Phase 2 Weight Loss (peak) ~14.9% ~20.9% 24.2% Approval Status FDA approved FDA approved Phase 3 trials A common question: is the difference between 20.9% (tirzepatide) and 24.2% (retatrutide) really that significant

Why it matters: An estimated 15.5 million US adults have used or are currently using GLP-1s for weight loss, according to Gallup

Reduction of cardiovascular risk and improved estimated glomerular filtration rate by SGLT2 inhibitors, including dapagliflozin, is consistent across the class: an analysis of the placebo arm of EXSCEL

Eli Lilly set Zepbounds direct-to-consumer price at $299$449/month depending on dose