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Biomarker-guided dosing in which formulation choice and dose are determined by confirmed plasma curcumin exposure and pre-treatment inflammatory status represents the most rigorous application of this framework and should be considered a design priority for future trials

Matsubara Y, Kiyohara H, Teratani T, Mikami Y, Kanai T

189 HSP90 also promotes the activation of oncogenic protein kinases such as JAK2/STAT3, PI3K/AKT, and MAPK, facilitating cancer progression