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The FDA did attach a boxed warning for embryo-fetal toxicity, flagging the risk of major birth defects when used during pregnancy
In experimental spinal cord injury models, GLPs preserve myelin ultrastructure and enhance functional recovery through multimodal neuroprotective actions: they suppress neuronal and oligodendroglial apoptosisevidenced by reduced caspase-3 cleavageattenuate neuroinflammation via downregulation of TNF- and myeloperoxidase (MPO) activity, and counteract oxidative damage by decreasing MDA and NO levels while boosting SOD activity
Front Endocrinol (Lausanne) (2020) 11:560
This prolonged retention might increase intragastric pressure and potentially promote retrograde movement of gastric contents into the esophagus, particularly in patients with pre-existing lower esophageal sphincter dysfunction or hiatal hernia
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