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Miao X, et al

Zheng, Y

Gene Expression Modulation Transcriptomic analyses in cellular models have shown that GHK-Cu influences expression of a remarkably wide set of genes, with reported effects on pathways involved in: Extracellular matrix remodeling DNA repair Antioxidant response Inflammatory signaling Stem cell signaling markers This broad transcriptional footprint has been one of the most studied aspects of GHK-Cu in recent years

The lack of these receptors ensures GI macrophages are unable to respond to ligands that would typically activate other immune cell types thereby preventing excessive IRs (Brenchley and Douek 2012)