what is a glp 1 drug GLP-1 medications get at the heart of addiction: study – WashU Medicine The GLP-1 Revolution: From Diabetes

2021 Jun 17;13(6):2073

Proteins assessed included components of the Erk1/2 and Akt pathways, markers of oxidative stress, insulin-like growth factor-1 (IGF-1), apoptotic regulators (Bax and Bcl-2), and autophagy-associated proteins

Cyanocobalamin, a slightly toxic, synthetic form, is especially dangerous to pernicious anemia patients

Brain cell metabolism was preserved in one trial, and the other found reduced amyloid-beta in extracellular vesicles, but neither trial found that GLP-1 drugs reduced the build-up of amyloid-beta in the brain or helped stave off cognitive decline

Targeted Pathway Support: Add-on therapies layered onto baseline therapy when symptoms suggest involvement of specific mediator pathways (e.g., leukotrienes or serotonin)