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Patients with severe heart failure or arrhythmias require monitoring because rapid shifts in free-fatty-acid metabolism can influence myocardial substrate utilization

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By delaying the rate at which food exits the stomach, semaglutide extends the postprandial period during which satiety hormones like GLP-1 and peptide YY remain elevated, suppressing the ghrelin rebound that typically triggers hunger 90120 minutes after eating

Cognitive symptoms alone rarely guide treatment decisions