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206 GLP-1 has also been shown to reduce blood glucose levels via direct inhibition of glucagon secretion from islet alpha-cells in an insulin-independent manner

Details on the isolation of mouse caSMCs and neonatal ventricular CMs, as well as cell culture methods for human caSMCs, caECs, hESC-CMs, and the HL-1 cell line, including drug treatment regimens, are provided in the Supplemental Methods

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GLP-1 receptor agonists have demonstrated glycaemic control, cardiovascular benefits in certain patient populations and significant weight reduction effects

Blood Sugar Levels Can Rise Again GLP-1 medications are powerful tools for improving glycemic control in type 2 diabetes