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A., Payne, N., Tortorelli, S., Matern, D., Rinaldo, P., Gavrilov, D., Melan, M., He, M., Steinberg, S

The improvement in pharmacokinetics helped prevent the negative gastrointestinal side effects typical of GLP- 1-based selective agonists by reducing maximum drug exposure and reducing reliance on GLP- 1-mediated pharmacology

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The addition of glutamate to folate derivatives traps the molecules in the cell and allows for accumulation in the mitochondria, a process required for the synthesis of glycine

doi: 10.1111/j.1600-0404.1999.tb07369.x 64