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Conclusions The findings illustrate that GLP-1RAs are associated with a lower risk of various hematologic cancers, especially MDS and MPN, in T2D patients

In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]

The rapid growth trajectory from initial filings in August 2023 to nearly 2,000 cases by August 2025 (with more ozempic lawsuits expected) reflects both the widespread use of these medications (with over 33 million patient-years of semaglutide exposure globally) and the severity of reported injuries

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