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These effects ultimately result in membrane destabilization, enzymatic inhibition, and dysfunction of signal transduction networks, causing metabolic imbalances that determine the threshold between adaptation and cell death

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Diagnostic methods Glutathione and sulphydryl compunds in erythrocytes can be measured using 5,5'-dithiobis (2-nitrobenzoic acid), while glutathione in fibroblasts can be measured with the 5,5'-dithiobis (2-nitrobenzoic acid) glutathione recycling assay [16], or using high performance liquid chromatography (HPLC) [17]