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383 Treg cells play a critical role in the immune system by suppressing the immune response and maintaining immune tolerance, whereas Th cells are involved mainly in the regulation and promotion of the immune response

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TRX has been found to be elevated in patients suffering from cancer and AIDS

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although they range in size, the proteins all encode a bZIP domain, and other domains associated with transcriptional activation and ubiquitin-binding, and protein-protein interaction (INT) (Fig