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The combination means GLP-1 patients in summer conditions are at meaningfully higher dehydration risk than either factor alone would create

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DW, dry weight

The variability in trial durations, ranging from 3 to 12 weeks across the included studies, and differences in the number of titration steps for each drug may further influence the reported incidence of gastrointestinal adverse events, particularly for agents like tirzepatide, where nausea risk escalates with higher doses (e.g., OR = 4.36, 95% CI: 3.425.61 at 10 mg) (Liu et al., 2025)

In addition, antibiotic resistance has a serious global economic impact