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When you don't have enough fluid to restore loss, your skin becomes duller with wrinkles and pores becoming more prominent

TUNEL assay On experimental day P38, pancreas samples were fixed in 2% w/v paraformaldehyde for 2 h and processed for TUNEL assay, which was performed using the One Step TUNEL Apoptosis Assay Kit (Beyotime, Shanghai, China) according to the manufacturers instructions

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It's that they address only surface-level symptoms while ignoring the deeper mechanisms that actually create and maintain wrinkles