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Rahim MN, Williamson C, Kametas NA, Heneghan MA

The work on animals in this study was carried out in accordance with the rules of the Institutional Review Board of the Ethical Committee of Animal Care and Use in Scientific Research of the Faculty of Veterinary Medicine, Minia University

10.1016/j.ccr.2007.08.004 Cancer Cell

The association between the genes of the -glutamyl cycle and autistic disorder is not well studied, although recently a relatively large study using a pathway approach showed a three-SNP joint interaction effect for glutaredoxin, glutaredoxin 3 and cystathione lyase (OR = 3.78, 95% CI: 2.36, 6.04) as well as marginal associations for cystathione lyase, the gamma-glutamylcysteine synthetase, catalytic subunit and glutaredoxin 3 suggesting that variation in genes involved in counterbalancing oxidative stress may contribute to autism [94]

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