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According to experts, "Because the weight loss happens so quickly, the skin doesnt always have time to adjust." Additionally, studies show that stopping these medications often results in weight regain, raising concerns about their long-term necessity and sustainability

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Twenty participants with obesity and at least 10% liver fat received either 25mg CB4211 via daily subcutaneous injection or placebo for 28 days

found that willingness to pay for GLP-1 drugs varies widely based on income